Pharmaceutical intermediate vacuum dryer

Material characteristics of pharmaceutical intermediates

Pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the pharmaceutical synthesis process. This chemical product does not require a production license for pharmaceuticals and can be produced in ordinary chemical plants, as long as it reaches some levels , which can be used for the synthesis of drugs.

Characteristics of pharmaceutical intermediate dryer equipment

Double cone rotary vacuum dryer is a drying equipment integrating mixing and vacuum drying. The process of vacuum drying is to place the material to be dried in a sealed cylinder, and use the vacuum system to vacuumize the material to be dried continuously, so that the moisture inside the material diffuses to the surface through the pressure difference or concentration difference, and water molecules (or other Non-condensable gas) obtains sufficient kinetic energy on the surface of the material, and after overcoming the mutual attraction between molecules, diffuses into the low-pressure space of the vacuum chamber, and is pumped away by the vacuum pump to complete the separation from the solid. Therefore, the double cone rotary vacuum dryer has the following characteristics: (1) In the process of vacuum drying, the pressure in the cylinder is always lower than the atmospheric pressure, the number of gas molecules is small, the density is low, and the oxygen content is low, so it can dry easily oxidized medicines and reduce the chance of material contamination. (2) Since the temperature of the moisture content is proportional to the steam pressure during the vaporization process, the moisture content in the material can be vaporized at low temperature during vacuum drying to achieve low temperature drying, which is especially suitable for the production of medicines with heat-sensitive materials. (3) Vacuum drying can eliminate the surface hardening phenomenon that is easily caused by normal pressure hot air drying. This is because the pressure difference between the vacuum drying material and the surface is large. Under the action of the pressure gradient, the water quickly moves to the surface, and the surface will not appear. hardening. (4) During vacuum drying, the temperature gradient between the inside and outside of the material is small, and the moisture can be moved and collected independently due to reverse osmosis, which effectively overcomes the dispersion phenomenon caused by hot air drying. Theory shows that the equipment also has the following characteristics: (1) the heating temperature is constant, the vacuum degree is increased, and the speed is accelerated; (2) the vacuum degree is constant, the heating temperature is increased, and the speed is accelerated; (3) both the vacuum degree and the heating temperature are increased. , the rate is greatly accelerated. (4) Hot water or steam can be used as the heating medium (steam pressure is 0.40-0.50Mpa); (5) The inner wall of the dryer adopts arc transition to avoid dead corners of sanitation and condensation of the solvent and drip into the contaminant flow in a layer of material tray.

Advantages of double cone rotary vacuum dryer for pharmaceutical intermediates

The machine is simple to operate, easy to feed and unload, which greatly reduces the labor intensity of workers, and also reduces the environmental pollution of materials during the drying process, improves product quality, and meets the requirements of the drug management standard "GMP".